In Vitro Release Testing (IVRT)
In Vitro Release Testing (IVRT) is a laboratory procedure used to evaluate the rate and extent of drug release from topical and transdermal formulations, such as creams, gels, ointments, and patches. This testing simulates how a drug is released from its formulation when applied to the skin, providing critical information about its performance before in vivo testing or clinical trials.
IVRT is well-established for characterizing and evaluating the performance of semi-solid dosage forms. IVRT is a valuable tool for demonstrating comparative in vitro drug release rates between the test and reference products (FDA). We perform IVRT studies across various synthetic membranes such as polysulfone, cellulose acetate/nitrate mixed ester, Polytetrafluoroethylene, polycarbonate.
